Pretty early in A Boy And His Blob you come across a couple of screens where Death in the form of these brown things rain down from the top of the screen. Most guides will tell you to use the Vanilla jellybean and use the Umbrella to protect yourself. But the Boy slips and slides around so much when you let off the cross-pad that I usually end up getting hit anyway.
So what I like to do is to use the Cola Jellybean instead to turn the Blob into a bubble.
That way it's impossible for me to get hit, since I'm protected on all sides.
And, yeah, you move a little slower, but I'd say that's a fair trade.