Comix Zone is tough, partially because you have one chance to get through the whole game, which means that you're going to be seeing this a lot:

So you might be tempted to go to the Jukebox

And you might be tempted to play the songs (by pressing the C button) in the following order:

3, 12, 17, 2 , 2, 10, 2, 7, 7, 11

And then you'll hear your character yell "Oh yeah!".

Start the game and you'll discover that you now have infinite health!

Which knocks out some of the challenge, true, but you can still die from falling in a pit or any of the other Instadeath(tm) methods in the game.

So it's not a total cakewalk.